Description
Tesamorelin is a peptide that triggers the secretion of growth hormone (GH) and is often prescribed to people with a deficiency of growth hormone (GH), particularly HIV patients. However, it’s also risen in popularity over the last few years among the bodybuilding community for its uses in enhancing recovery and facilitating muscle growth.
How does it work?:
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As tesamorelin mimics the action of a naturally occurring endogenous hormone, it also acts on specific target sites. Hence, the mechanism of action followed by tesamorelin is very specific.
Tesamorelin binds to the growth hormone-releasing hormone receptors (GHRHr) located in the anterior pituitary gland. This binding stimulates the somatotrophic cells in the pituitary gland to synthesize and secrete growth hormone (GH).
Growth hormone (GH) acts primarily on adipocytes (fat cells), hepatocytes (liver cells), myocytes (muscle cells), and osteoblasts (bone cells).
To ensure the tesamorelin-induced release of growth hormone (GH) is within set limits, a negative feedback mechanism is initiated, so that serum growth hormone (GH) levels don’t overshoot.
As tesamorelin triggers the release of growth hormone (GH) naturally, it maintains homeostatic coordination between Hypothalamus and pituitary gland.
Use for bodybuilding:
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Tesamorelin, a Growth Hormone Releasing Hormone analog, works by stimulating the release of Growth Hormone, which in turn increases the levels of Insulin-Like Growth Factor-1 (IGF-1). It is IGF-1 that mediates the specific benefits associated with bodybuilding.
According to studies, IGF-1 promotes muscle proliferation through satellite cells, decreases muscle breakdown, and also prevents toxin-induced inflammation of muscles. If you’re specifically using Tesamorelin for bodybuilding, 1 mg of injection 90 minutes before eating is usually advised. You can use it for 5 days straight, followed by 2 days off, and repeating the cycle.
